Conformation and recognition of DNA modified by a new antitumor dinuclear Pt(II) complex resistant to decomposition by sulfur nucleophiles

Reported herein is a detailed biochemical and molecular biophysics study of the molecular mechanism of action of antitumor dinuclear Pt(II) complex [{PtCl(DACH)}(2)-μ-Y](4+) [DACH = 1,2-diaminocyclohexane, Y =H(2)N(CH(2))(6)NH(2)(CH(2))(2)NH(2)(CH(2))(6)NH(2)] (complex 1). This new, long-chain bifun...

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Main Authors: Zerzankova, Lenka, Suchankova, Tereza, Vrana, Oldrich, Farrell, Nicholas P., Brabec, Viktor, Kasparkova, Jana
格式: Artigo
語言:Inglês
出版: 2009
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078055/
https://ncbi.nlm.nih.gov/pubmed/19682435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2009.08.009
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