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Differential recognition by the tumor suppressor protein p53 of DNA modified by the novel antitumor trinuclear platinum drug BBR3464 and cisplatin

The trinuclear platinum agent BBR3464, a representative of a new class of anticancer drugs, is more potent than conventional mononuclear cisplatin [cis-diamminedichloroplatinum(II)]. BBR3464 retains significant activity in human tumor cell lines and xenografts that are refractory or poorly responsiv...

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Bibliografische gegevens
Gepubliceerd in:Nucleic Acids Res
Hoofdauteurs: Kasparkova, Jana, Fojta, Miroslav, Farrell, Nicholas, Brabec, Viktor
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2004
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Online toegang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC524304/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15486204/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkh896
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