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Differential recognition by the tumor suppressor protein p53 of DNA modified by the novel antitumor trinuclear platinum drug BBR3464 and cisplatin

The trinuclear platinum agent BBR3464, a representative of a new class of anticancer drugs, is more potent than conventional mononuclear cisplatin [cis-diamminedichloroplatinum(II)]. BBR3464 retains significant activity in human tumor cell lines and xenografts that are refractory or poorly responsiv...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kasparkova, Jana, Fojta, Miroslav, Farrell, Nicholas, Brabec, Viktor
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2004
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC524304/
https://ncbi.nlm.nih.gov/pubmed/15486204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh896
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