Amide-Based Prodrugs of Spermidine-Bridged Dinuclear Platinum. Synthesis, DNA Binding, and Biological Activity

The chemistry and biology of acetyl-protected spermidine-bridged dinuclear platinum complexes [{trans-PtCl(NH(3))(2)](2)-μ-NH(2)(CH(2))(3)N(COR)(CH(2))(4)NH(2)]X(2) (R = H, X = Cl (1,1/t,t-spermidine, BBR3571); R = CH(3,) X = Cl (2); R = CH(2) Cl, X = ClO(4) (3); R = CF(3,) X = Cl (4)) are compared...

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Main Authors: Hegmans, Alexander, Kasparkova, Jana, Vrana, Oldrich, Kelland, Lloyd R., Brabec, Viktor, Farrell, Nicholas P.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2803320/
https://ncbi.nlm.nih.gov/pubmed/18338842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm070813z
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