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Inhibition of nuclear factor kappaB proteins-platinated DNA interactions correlates with cytotoxic effectiveness of the platinum complexes

Nuclear DNA is the target responsible for anticancer activity of platinum anticancer drugs. Their activity is mediated by altered signals related to programmed cell death and the activation of various signaling pathways. An example is activation of nuclear factor kappaB (NF-κB). Binding of NF-κB pro...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Brabec, Viktor, Kasparkova, Jana, Kostrhunova, Hana, Farrell, Nicholas P.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004165/
https://ncbi.nlm.nih.gov/pubmed/27574114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28474
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