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DNA bending and unwinding due to the major 1,2-GG intrastrand cross-link formed by antitumor cis-diamminedichloroplatinum(II) are flanking-base independent

Antitumor cisplatin [cis-diamminedichloroplatinum(II)] forms on DNA predominantly intrastrand cross-links between neighboring purine residues. Several discoveries suggested that the toxicity of cisplatin originated from these lesions. The formation of 1,2-GG intrastrand cross-link of cisplatin leads...

詳細記述

保存先:
書誌詳細
主要な著者: Stehlikova, Kristyna, Kostrhunova, Hana, Kasparkova, Jana, Brabec, Viktor
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2002
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC117060/
https://ncbi.nlm.nih.gov/pubmed/12087174
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