DNA bending and unwinding due to the major 1,2-GG intrastrand cross-link formed by antitumor cis-diamminedichloroplatinum(II) are flanking-base independent
Antitumor cisplatin [cis-diamminedichloroplatinum(II)] forms on DNA predominantly intrastrand cross-links between neighboring purine residues. Several discoveries suggested that the toxicity of cisplatin originated from these lesions. The formation of 1,2-GG intrastrand cross-link of cisplatin leads...
Na minha lista:
| Publicado no: | Nucleic Acids Res |
|---|---|
| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2002
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC117060/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12087174/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkf405 |
| Tags: |
Sem tags, seja o primeiro a adicionar uma tag!
|