Superhelical torsion controls DNA interstrand cross-linking by antitumor cis- diamminedichloroplatinum(II).

Negatively supercoiled, relaxed and linearized forms of pSP73 DNA were modified in cell-free medium by cis-diamminedichloroplatinum(II) (cisplatin). The frequency of interstrand cross-links (ICLs) formed in these DNAs has been determined by: (i) immunochemical analysis; (ii) an assay employing NaCN...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Vrána, O, Boudný, V, Brabec, V
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146196/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8918792/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/24.20.3918
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