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Formation of cis-diamminedichloroplatinum(II) 1,2-intrastrand cross-links on DNA is flanking-sequence independent

Mapping of cis-diamminedichloroplatinum(II) (cis-DDP, cisplatin) DNA adducts over >3000 nucleotides was carried out using a replication blockage assay. The sites of inhibition of modified T4 DNA polymerase, also referred to as stop sites, were analyzed to determine the effects of local sequence c...

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Bibliografski detalji
Glavni autori: Burstyn, Judith N., Heiger-Bernays, Wendy J., Cohen, Seth M., Lippard, Stephen J.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2000
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC113142/
https://ncbi.nlm.nih.gov/pubmed/11058123
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