DNA interstrand cross-links of trans-diamminedichloroplatinum(II) are preferentially formed between guanine and complementary cytosine residues.

Bases in the opposite strands of DNA cross-linked by clinically ineffective trans-diamminedichloroplatinum(II) (trans-[Pt(NH3)2Cl2]) have been identified by means of three experimental approaches. These include HPLC analysis of enzymatic digests of synthetic oligonucleotide duplexes containing the i...

Full description

Saved in:
Bibliographic Details
Main Authors: Brabec, V, Leng, M
Format: Artigo
Language:Inglês
Published: 1993
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC46713/
https://ncbi.nlm.nih.gov/pubmed/8506383
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items