Superhelical torsion controls DNA interstrand cross-linking by antitumor cis- diamminedichloroplatinum(II).
Negatively supercoiled, relaxed and linearized forms of pSP73 DNA were modified in cell-free medium by cis-diamminedichloroplatinum(II) (cisplatin). The frequency of interstrand cross-links (ICLs) formed in these DNAs has been determined by: (i) immunochemical analysis; (ii) an assay employing NaCN...
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| Udgivet i: | Nucleic Acids Res |
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| Principais autores: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
1996
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146196/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8918792/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/24.20.3918 |
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