DNA bending and unwinding due to the major 1,2-GG intrastrand cross-link formed by antitumor cis-diamminedichloroplatinum(II) are flanking-base independent

Antitumor cisplatin [cis-diamminedichloroplatinum(II)] forms on DNA predominantly intrastrand cross-links between neighboring purine residues. Several discoveries suggested that the toxicity of cisplatin originated from these lesions. The formation of 1,2-GG intrastrand cross-link of cisplatin leads...

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Опубликовано в::	Nucleic Acids Res
Главные авторы:	Stehlikova, Kristyna, Kostrhunova, Hana, Kasparkova, Jana, Brabec, Viktor
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Oxford University Press 2002
Предметы:	Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC117060/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12087174/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkf405
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