A potent cytotoxic photoactivated platinum complex

We show by x-ray crystallography that the complex trans, trans, trans-[Pt(N(3))(2)(OH)(2)(NH(3))(py)] (1) contains an octahedral Pt(IV) center with almost linear azido ligands. Complex 1 is remarkably stable in the dark, even in the presence of cellular reducing agents such as glutathione, but readi...

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Detalhes bibliográficos
Main Authors: Mackay, Fiona S., Woods, Julie A., Heringová, Pavla, Kašpárková, Jana, Pizarro, Ana M., Moggach, Stephen A., Parsons, Simon, Brabec, Viktor, Sadler, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2410072/
https://ncbi.nlm.nih.gov/pubmed/18093923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707742105
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