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Chiral discrimination in platinum anticancer drugs.

In this article we review the biological activity of analogs of the antitumor drug cisplatin that contain chiral amine ligands. Interaction with DNA and formation of cross-links with adjacent purine bases are considered to be the crucial steps in the antitumor activity of this class of complexes. Be...

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Bibliografische gegevens
Hoofdauteurs: Benedetti, Michele, Malina, Jaroslav, Kasparkova, Jana, Brabec, Viktor, Natile, Giovanni
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2002
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1241244/
https://ncbi.nlm.nih.gov/pubmed/12426131
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