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Chiral discrimination in platinum anticancer drugs.

In this article we review the biological activity of analogs of the antitumor drug cisplatin that contain chiral amine ligands. Interaction with DNA and formation of cross-links with adjacent purine bases are considered to be the crucial steps in the antitumor activity of this class of complexes. Be...

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書誌詳細
主要な著者: Benedetti, Michele, Malina, Jaroslav, Kasparkova, Jana, Brabec, Viktor, Natile, Giovanni
フォーマット: Artigo
言語:Inglês
出版事項: 2002
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1241244/
https://ncbi.nlm.nih.gov/pubmed/12426131
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