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Ligand modulation of a dinuclear platinum compound leads to mechanistic differences in cell cycle progression and arrest
Despite similar structures and DNA binding profiles, two recently synthesized dinuclear platinum compounds are shown to elicit highly divergent effects on cell cycle progression. In colorectal HCT116 cells, BBR3610 shows a classical G(2)/M arrest with initial accumulation in S phase, but the derivat...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3932533/ https://ncbi.nlm.nih.gov/pubmed/24161784 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2013.10.012 |
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