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Ligand modulation of a dinuclear platinum compound leads to mechanistic differences in cell cycle progression and arrest

Despite similar structures and DNA binding profiles, two recently synthesized dinuclear platinum compounds are shown to elicit highly divergent effects on cell cycle progression. In colorectal HCT116 cells, BBR3610 shows a classical G(2)/M arrest with initial accumulation in S phase, but the derivat...

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Detaylı Bibliyografya
Asıl Yazarlar: Menon, Vijay R., Peterson, Erica J., Valerie, Kristoffer, Farrell, Nicholas P., Povirk, Lawrence F.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3932533/
https://ncbi.nlm.nih.gov/pubmed/24161784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2013.10.012
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