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PLATINUM-BASED DRUGS AND PROTEINS: REACTIVITY AND RELEVANCE TO DNA ADDUCT FORMATION

The mechanism of action of clinically used Pt-based drugs is through the formation of stable DNA adducts occurring at the nitrogen in position 7 of guanine (N7) and involving one or two spatially closed residues. Nevertheless, proteins can represent alternative targets since in particular sulphur gr...

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Detalhes bibliográficos
Main Authors: Pinato, Odra, Musetti, Caterina, Farrell, Nicholas P., Sissi, Claudia
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602126/
https://ncbi.nlm.nih.gov/pubmed/23435290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinorgbio.2013.01.007
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