Platinum-DNA adduct formation in leucocytes of children in relation to pharmacokinetics after cisplatin and carboplatin therapy.

Platinum (Pt)-DNA adducts were measured in peripheral blood leucocytes (PBLs) from 24 children with solid tumours after standard cisplatin and/or carboplatin treatment. The relationship between Pt-DNA adduct levels and pharmacokinetics of cisplatin and carboplatin was investigated. Adduct measuremen...

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Main Authors: Peng, B., Tilby, M. J., English, M. W., Price, L., Pearson, A. D., Boddy, A. V., Newell, D. R.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1997
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2228168/
https://ncbi.nlm.nih.gov/pubmed/9400943
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