Genetics of gene expression in immunity to infection

Por Fairfax, Benjamin P, Knight, Julian C
Publicado no Curr Opin Immunol (2014)

Fine mapping genetic determinants of the highly variably expressed MHC gene ZFP57

Por Plant, Katharine, Fairfax, Benjamin P, Makino, Seiko, Vandiedonck, Claire, Radhakrishnan, Jayachandran, Knight, Julian C
Publicado em 2014

A COMMON HAPLOTYPE OF THE TUMOUR NECROSIS FACTOR RECEPTOR 2 GENE MODULATES ENDOTOXIN TOLERANCE

Por Fairfax, Benjamin P., Davenport, Emma E., Makino, Seiko, Hill, Adrian V.S., Vannberg, Fredrik O., Knight, Julian C.
Publicado em 2011

An integrated expression phenotype mapping approach defines common variants in LEP, ALOX15 and CAPNS1 associated with induction of IL-6

Por Fairfax, Benjamin P., Vannberg, Fredrik O., Radhakrishnan, Jayachandran, Hakonarson, Hakon, Keating, Brendan J., Hill, Adrian V.S., Knight, Julian C.
Publicado em 2010

Genomic modulators of gene expression in human neutrophils

Por Naranbhai, Vivek, Fairfax, Benjamin P., Makino, Seiko, Humburg, Peter, Wong, Daniel, Ng, Esther, Hill, Adrian V. S., Knight, Julian C.
Publicado no Nat Commun (2015)

Pervasive haplotypic variation in the spliceo-transcriptome of the human major histocompatibility complex

Por Vandiedonck, Claire, Taylor, Martin S., Lockstone, Helen E., Plant, Katharine, Taylor, Jennifer M., Durrant, Caroline, Broxholme, John, Fairfax, Benjamin P., Knight, Julian C.
Publicado em 2011

Genomic mapping of the MHC transactivator CIITA using an integrated ChIP-seq and genetical genomics approach

Por Wong, Daniel, Lee, Wanseon, Humburg, Peter, Makino, Seiko, Lau, Evelyn, Naranbhai, Vivek, Fairfax, Benjamin P, Chan, Kenneth, Plant, Katharine, Knight, Julian C
Publicado no Genome Biol (2014)

GENETICS OF GENE EXPRESSION IN PRIMARY IMMUNE CELLS IDENTIFIES CELL-SPECIFIC MASTER REGULATORS AND ROLES OF HLA ALLELES

Por Fairfax, Benjamin P, Makino, Seiko, Radhakrishnan, Jayachandran, Plant, Katharine, Leslie, Stephen, Dilthey, Alexander, Ellis, Peter, Langford, Cordelia, Vannberg, Fredrik O, Knight, Julian C
Publicado em 2012

Distinct Transcriptional and Anti-Mycobacterial Profiles of Peripheral Blood Monocytes Dependent on the Ratio of Monocytes: Lymphocytes

Por Naranbhai, Vivek, Fletcher, Helen A., Tanner, Rachel, O'Shea, Matthew K., McShane, Helen, Fairfax, Benjamin P., Knight, Julian C., Hill, Adrian V.S.
Publicado no EBioMedicine (2015)

HLA-C Level Is Regulated by a Polymorphic Oct1 Binding Site in the HLA-C Promoter Region

Por Vince, Nicolas, Li, Hongchuan, Ramsuran, Veron, Naranbhai, Vivek, Duh, Fuh-Mei, Fairfax, Benjamin P., Saleh, Bahara, Knight, Julian C., Anderson, Stephen K., Carrington, Mary
Publicado no Am J Hum Genet (2016)

Innate Immune Activity Conditions the Effect of Regulatory Variants upon Monocyte Gene Expression

Por Fairfax, Benjamin P., Humburg, Peter, Makino, Seiko, Naranbhai, Vivek, Wong, Daniel, Lau, Evelyn, Jostins, Luke, Plant, Katharine, Andrews, Robert, McGee, Chris, Knight, Julian C.
Publicado em 2014

Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4(+) versus CD8(+) T cells

Por Kasela, Silva, Kisand, Kai, Tserel, Liina, Kaleviste, Epp, Remm, Anu, Fischer, Krista, Esko, Tõnu, Westra, Harm-Jan, Fairfax, Benjamin P., Makino, Seiko, Knight, Julian C., Franke, Lude, Metspalu, Andres, Peterson, Pärt, Milani, Lili
Publicado no PLoS Genet (2017)

Whole-genome sequencing identifies homozygous BRCA2 deletion guiding treatment in dedifferentiated prostate cancer

Por Purshouse, Karin, Schuh, Anna, Fairfax, Benjamin P., Knight, Sam, Antoniou, Pavlos, Dreau, Helene, Popitsch, Niko, Gatter, Kevin, Roberts, Ian, Browning, Lisa, Traill, Zoe, Kerr, David, Verrill, Clare, Tuthill, Mark, Taylor, Jenny C., Protheroe, Andrew
Publicado no Cold Spring Harb Mol Case Stud (2017)

Phospho-dependent functional modulation of GABA(B) receptors by the metabolic sensor AMP-dependent protein kinase

Por Kuramoto, Nobuyuki, Wilkins, Megan E, Fairfax, Benjamin P, Revilla-Sanchez, Raquel, Terunuma, Miho, Warren, Noel, Tamaki, Keisuke, Iemata, Mika, Couve, Andrés, Calver, Andrew, Horvath, Zsolt, Freeman, Katie, Carling, David, Huang, Lan, Gonzales, Cathleen, Cooper, Edward, Smart, Trevor G., Pangalos, Menelas N., Moss., Stephen J.
Publicado em 2007

Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus

Por Bentham, James, Morris, David L, Graham, Deborah S Cunninghame, Pinder, Christopher L, Tombleson, Philip, Behrens, Timothy W, Martín, Javier, Fairfax, Benjamin P, Knight, Julian C, Chen, Lingyan, Replogle, Joseph, Syvänen, Ann-Christine, Rönnblom, Lars, Graham, Robert R, Wither, Joan E, Rioux, John D, Alarcón-Riquelme, Marta E, Vyse, Timothy J
Publicado no Nat Genet (2015)

Increased prevalence of sex chromosome aneuploidies in specific language impairment and dyslexia

Por Simpson, Nuala H, Addis, Laura, Brandler, William M, Slonims, Vicky, Clark, Ann, Watson, Jocelynne, Scerri, Thomas S, Hennessy, Elizabeth R, Bolton, Patrick F, Conti-Ramsden, Gina, Fairfax, Benjamin P, Knight, Julian C, Stein, John, Talcott, Joel B, O'Hare, Anne, Baird, Gillian, Paracchini, Silvia, Fisher, Simon E, Newbury, Dianne F, Consortium, SLI
Publicado no Dev Med Child Neurol (2014)

Risk of nontyphoidal Salmonella bacteraemia in African children is modified by STAT4

Por Gilchrist, James J., Rautanen, Anna, Fairfax, Benjamin P., Mills, Tara C., Naranbhai, Vivek, Trochet, Holly, Pirinen, Matti, Muthumbi, Esther, Mwarumba, Salim, Njuguna, Patricia, Mturi, Neema, Msefula, Chisomo L., Gondwe, Esther N., MacLennan, Jenny M., Chapman, Stephen J., Molyneux, Malcolm E., Knight, Julian C., Spencer, Chris C. A., Williams, Thomas N., MacLennan, Calman A., Scott, J. Anthony G., Hill, Adrian V. S.
Publicado no Nat Commun (2018)

A functional SNP associated with atopic dermatitis controls cell type-specific methylation of the VSTM1 gene locus

Por Kumar, Dilip, Puan, Kia Joo, Andiappan, Anand Kumar, Lee, Bernett, Westerlaken, Geertje H. A., Haase, Doreen, Melchiotti, Rossella, Li, Zhuang, Yusof, Nurhashikin, Lum, Josephine, Koh, Geraldine, Foo, Shihui, Yeong, Joe, Alves, Alexessander Couto, Pekkanen, Juha, Sun, Liang Dan, Irwanto, Astrid, Fairfax, Benjamin P., Naranbhai, Vivek, Common, John E. A., Tang, Mark, Chuang, Chin Keh, Jarvelin, Marjo-Riitta, Knight, Julian C., Zhang, Xuejun, Chew, Fook Tim, Prabhakar, Shyam, Jianjun, Liu, Wang, De Yun, Zolezzi, Francesca, Poidinger, Michael, Lane, E. Birgitte, Meyaard, Linde, Rötzschke, Olaf
Publicado no Genome Med (2017)

Leprosy and the Adaptation of Human Toll-Like Receptor 1

Por Wong, Sunny H., Gochhait, Sailesh, Malhotra, Dheeraj, Pettersson, Fredrik H., Teo, Yik Y., Khor, Chiea C., Rautanen, Anna, Chapman, Stephen J., Mills, Tara C., Srivastava, Amit, Rudko, Aleksey, Freidin, Maxim B., Puzyrev, Valery P., Ali, Shafat, Aggarwal, Shweta, Chopra, Rupali, Reddy, Belum S. N., Garg, Vijay K., Roy, Suchismita, Meisner, Sarah, Hazra, Sunil K., Saha, Bibhuti, Floyd, Sian, Keating, Brendan J., Kim, Cecilia, Fairfax, Benjamin P., Knight, Julian C., Hill, Philip C., Adegbola, Richard A., Hakonarson, Hakon, Fine, Paul E. M., Pitchappan, Ramasamy M., Bamezai, Rameshwar N. K., Hill, Adrian V. S., Vannberg, Fredrik O.
Publicado em 2010

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer’s disease

Por Huang, Kuan-lin, Marcora, Edoardo, Pimenova, Anna A, Di Narzo, Antonio F, Kapoor, Manav, Jin, Sheng Chih, Harari, Oscar, Bertelsen, Sarah, Fairfax, Benjamin P, Czajkowski, Jake, Chouraki, Vincent, Grenier-Boley, Benjamin, Bellenguez, Céline, Deming, Yuetiva, McKenzie, Andrew, Raj, Towfique, Renton, Alan E, Budde, John, Smith, Albert, Fitzpatrick, Annette, Bis, Joshua C, DeStefano, Anita, Adams, Hieab HH, Ikram, M Arfan, van der Lee, Sven, Del-Aguila, Jorge L., Fernandez, Maria Victoria, Ibañez, Laura, Sims, Rebecca, Escott-Price, Valentina, Mayeux, Richard, Haines, Jonathan L, Farrer, Lindsay A, Pericak-Vance, Margaret A., Lambert, Jean Charles, van Duijn, Cornelia, Launer, Lenore, Seshadri, Sudha, Williams, Julie, Amouyel, Philippe, Schellenberg, Gerard D, Zhang, Bin, Borecki, Ingrid, Kauwe, John S K, Cruchaga, Carlos, Hao, Ke, Goate, Alison M
Publicado no Nat Neurosci (2017)