Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus

Systemic lupus erythematosus (SLE; OMIM 152700) is a genetically complex autoimmune disease characterized by loss of immune tolerance to nuclear and cell surface antigens. Previous genome-wide association studies (GWAS) had modest sample sizes, reducing their scope and reliability. Our study compris...

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Publicado no:Nat Genet
Main Authors: Bentham, James, Morris, David L, Graham, Deborah S Cunninghame, Pinder, Christopher L, Tombleson, Philip, Behrens, Timothy W, Martín, Javier, Fairfax, Benjamin P, Knight, Julian C, Chen, Lingyan, Replogle, Joseph, Syvänen, Ann-Christine, Rönnblom, Lars, Graham, Robert R, Wither, Joan E, Rioux, John D, Alarcón-Riquelme, Marta E, Vyse, Timothy J
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4668589/
https://ncbi.nlm.nih.gov/pubmed/26502338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3434
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