Genomic mapping of the MHC transactivator CIITA using an integrated ChIP-seq and genetical genomics approach

BACKGROUND: The master transactivator CIITA is essential to the regulation of Major Histocompatibility Complex (MHC) class II genes and an effective immune response. CIITA is known to modulate a small number of non-MHC genes involved in antigen presentation such as CD74 and B2M but its broader genom...

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Bibliografiske detaljer
Udgivet i:Genome Biol
Main Authors: Wong, Daniel, Lee, Wanseon, Humburg, Peter, Makino, Seiko, Lau, Evelyn, Naranbhai, Vivek, Fairfax, Benjamin P, Chan, Kenneth, Plant, Katharine, Knight, Julian C
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4243378/
https://ncbi.nlm.nih.gov/pubmed/25366989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-014-0494-z
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