GENETICS OF GENE EXPRESSION IN PRIMARY IMMUNE CELLS IDENTIFIES CELL-SPECIFIC MASTER REGULATORS AND ROLES OF HLA ALLELES

Trans-acting genetic variants play a substantial, albeit poorly characterized, role in the heritable determination of gene expression. Using paired purified primary monocytes and B-cells we identify novel, predominantly cell-specific, cis- and trans-eQTL (expression quantitative trait loci). These i...

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Main Authors: Fairfax, Benjamin P, Makino, Seiko, Radhakrishnan, Jayachandran, Plant, Katharine, Leslie, Stephen, Dilthey, Alexander, Ellis, Peter, Langford, Cordelia, Vannberg, Fredrik O, Knight, Julian C
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437404/
https://ncbi.nlm.nih.gov/pubmed/22446964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2205
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