Is there a causal link between intracellular Na elevation and metabolic remodelling in cardiac hypertrophy?

Por Aksentijevic, Dunja, O'Brien, Brett A., Eykyn, Thomas R., Shattock, Michael J.
Publicado no Biochem Soc Trans (2018)

Detection of the prodrug-activating enzyme carboxypeptidase G2 activity with chemical exchange saturation transfer magnetic resonance

Por Jamin, Yann, Eykyn, Thomas R., Poon, Evon, Springer, Caroline J., Robinson, Simon P.
Publicado no Mol Imaging Biol (2014)

Multiple quantum filtered (23)Na NMR in the Langendorff perfused mouse heart: Ratio of triple/double quantum filtered signals correlates with [Na](i)

Por Eykyn, Thomas R., Aksentijević, Dunja, Aughton, Karen L., Southworth, Richard, Fuller, William, Shattock, Michael J.
Publicado no J Mol Cell Cardiol (2015)

Assessing radiotracer kinetics in the Langendorff perfused heart

Por Mariotti, Erika, Veronese, Mattia, Dunn, Joel T, Medina, Rodolfo A, Blower, Philip J, Southworth, Richard, Eykyn, Thomas R
Publicado em 2013

Modeling non‐linear kinetics of hyperpolarized [1‐(13)C] pyruvate in the crystalloid‐perfused rat heart

Por Mariotti, E., Orton, M. R., Eerbeek, O., Ashruf, J. F., Zuurbier, C. J., Southworth, R., Eykyn, T. R.
Publicado no NMR Biomed (2016)

Modification of intracellular glutathione status does not change the cardiac trapping of (64)Cu(ATSM)

Por Shaughnessy, Fiona, Mariotti, Erika, Shaw, Karen P, Eykyn, Thomas R, Blower, Philip J, Siow, Richard, Southworth, Richard
Publicado no EJNMMI Res (2014)

Contractile function assessment by intraventricular balloon alters the ability of regional ischaemia to evoke ventricular fibrillation

Por Wilder, Catherine D E, Masoud, Radwa, Yazar, Duygu, O'Brien, Brett A, Eykyn, Thomas R, Curtis, Michael J
Publicado no Br J Pharmacol (2015)

Cardiac Hypoxia Imaging: Second-Generation Analogues of (64)Cu-ATSM

Por Handley, Maxwell G., Medina, Rodolfo A., Mariotti, Erika, Kenny, Gavin D., Shaw, Karen P., Yan, Ran, Eykyn, Thomas R., Blower, Philip J., Southworth, Richard
Publicado no J Nucl Med (2014)

(1)H-NMR and Hyperpolarized (13)C-NMR Assays of Pyruvate-Lactate Exhange: a comparative study

Por Hill, Deborah K., Jamin, Yann, Orton, Matthew R., Tardif, Nicolas, Parkes, Harold G., Robinson, Simon P., Leach, Martin O., Chung, Yuen-Li, Eykyn, Thomas R.
Publicado no NMR Biomed (2013)

MCT1 inhibitor AZD3965 increases mitochondrial metabolism, facilitating combination therapy and non-invasive magnetic resonance spectroscopy

Por Beloueche-Babari, Mounia, Wantuch, Slawomir, Casals Galobart, Teresa, Koniordou, Markella, Parkes, Harold G, Arunan, Vaitha, Chung, Yuen-Li, Eykyn, Thomas R, Smith, Paul D, Leach, Martin O
Publicado no Cancer Res (2017)

Upregulation of Glucose Uptake and Hexokinase Activity of Primary Human CD4+ T Cells in Response to Infection with HIV-1

Por Kavanagh Williamson, Maia, Coombes, Naomi, Juszczak, Florian, Athanasopoulos, Marios, Khan, Mariam B., Eykyn, Thomas R., Srenathan, Ushani, Taams, Leonie S., Dias Zeidler, Julianna, Da Poian, Andrea T., Huthoff, Hendrik
Publicado no Viruses (2018)

Comparison of macrocyclic and acyclic chelators for gallium-68 radiolabelling

Por Tsionou, Maria Iris, Knapp, Caroline E., Foley, Calum A., Munteanu, Catherine R., Cakebread, Andrew, Imberti, Cinzia, Eykyn, Thomas R., Young, Jennifer D., Paterson, Brett M., Blower, Philip J., Ma, Michelle T.
Publicado no RSC Adv (2017)

Simultaneous Assessment of Cardiac Inflammation and Extracellular Matrix Remodeling after Myocardial Infarction

Por Ramos, Isabel T., Henningsson, Markus, Nezafat, Maryam, Lavin, Begoña, Lorrio, Silvia, Gebhardt, Pierre, Protti, Andrea, Eykyn, Thomas R., Andia, Marcelo E., Flögel, Ulrich, Phinikaridou, Alkystis, Shah, Ajay M., Botnar, René M.
Publicado no Circ Cardiovasc Imaging (2018)

Lactate and Choline Metabolites Detected In Vitro by Nuclear Magnetic Resonance Spectroscopy Are Potential Metabolic Biomarkers for PI3K Inhibition in Pediatric Glioblastoma

Por Al-Saffar, Nada M. S., Marshall, Lynley V., Jackson, L. Elizabeth, Balarajah, Geetha, Eykyn, Thomas R., Agliano, Alice, Clarke, Paul A., Jones, Chris, Workman, Paul, Pearson, Andrew D. J., Leach, Martin O.
Publicado em 2014

Proteomic and metabolomic changes driven by elevating myocardial creatine suggest novel metabolic feedback mechanisms

Por Zervou, Sevasti, Yin, Xiaoke, Nabeebaccus, Adam A., O’Brien, Brett A., Cross, Rebecca L., McAndrew, Debra J., Atkinson, R. Andrew, Eykyn, Thomas R., Mayr, Manuel, Neubauer, Stefan, Lygate, Craig A.
Publicado no Amino Acids (2016)

Over-expression of mitochondrial creatine kinase in the murine heart improves functional recovery and protects against injury following ischaemia–reperfusion

Por Whittington, Hannah J, Ostrowski, Philip J, McAndrew, Debra J, Cao, Fang, Shaw, Andrew, Eykyn, Thomas R, Lake, Hannah A, Tyler, Jack, Schneider, Jurgen E, Neubauer, Stefan, Zervou, Sevasti, Lygate, Craig A
Publicado no Cardiovasc Res (2018)

Reduced Warburg Effect in Cancer Cells Undergoing Autophagy: Steady- State (1)H-MRS and Real-Time Hyperpolarized (13)C-MRS Studies

Por Lin, Gigin, Andrejeva, Gabriela, Wong Te Fong, Anne-Christine, Hill, Deborah K., Orton, Matthew R., Parkes, Harry G., Koh, Dow-Mu, Robinson, Simon P., Leach, Martin O., Eykyn, Thomas R., Chung, Yuen-Li
Publicado em 2014

Model Free Approach to Kinetic Analysis of Real-Time Hyperpolarized (13)C Magnetic Resonance Spectroscopy Data

Por Hill, Deborah K., Orton, Matthew R., Mariotti, Erika, Boult, Jessica K. R., Panek, Rafal, Jafar, Maysam, Parkes, Harold G., Jamin, Yann, Miniotis, Maria Falck, Al-Saffar, Nada M. S., Beloueche-Babari, Mounia, Robinson, Simon P., Leach, Martin O., Chung, Yuen-Li, Eykyn, Thomas R.
Publicado em 2013

Nox4 reprograms cardiac substrate metabolism via protein O-GlcNAcylation to enhance stress adaptation

Por Nabeebaccus, Adam A., Zoccarato, Anna, Hafstad, Anne D., Santos, Celio X.C., Aasum, Ellen, Brewer, Alison C., Zhang, Min, Beretta, Matteo, Yin, Xiaoke, West, James A., Schröder, Katrin, Griffin, Julian L., Eykyn, Thomas R., Abel, E. Dale, Mayr, Manuel, Shah, Ajay M.
Publicado no JCI Insight (2017)

Dichloroacetate induces autophagy in colorectal cancer cells and tumours

Por Lin, G, Hill, D K, Andrejeva, G, Boult, J K R, Troy, H, Fong, A-C L F W T, Orton, M R, Panek, R, Parkes, H G, Jafar, M, Koh, D-M, Robinson, S P, Judson, I R, Griffiths, J R, Leach, M O, Eykyn, T R, Chung, Y-L
Publicado em 2014