Proteomic and metabolomic changes driven by elevating myocardial creatine suggest novel metabolic feedback mechanisms

Mice over-expressing the creatine transporter have elevated myocardial creatine levels [Cr] and are protected against ischaemia/reperfusion injury via improved energy reserve. However, mice with very high [Cr] develop cardiac hypertrophy and dysfunction. To investigate these contrasting effects, we...

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Detalhes bibliográficos
Publicado no:Amino Acids
Main Authors: Zervou, Sevasti, Yin, Xiaoke, Nabeebaccus, Adam A., O’Brien, Brett A., Cross, Rebecca L., McAndrew, Debra J., Atkinson, R. Andrew, Eykyn, Thomas R., Mayr, Manuel, Neubauer, Stefan, Lygate, Craig A.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Vienna 2016
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4974297/
https://ncbi.nlm.nih.gov/pubmed/27143170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00726-016-2236-x
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