Chronic creatine kinase deficiency eventually leads to congestive heart failure, but severity is dependent on genetic background, gender and age

The creatine kinase (CK) energy transport and buffering system supports cardiac function at times of high demand and is impaired in the failing heart. Mice deficient in muscle- and mitochondrial-CK (M/Mt-CK(−/−)) have previously been described, but exhibit an unexpectedly mild phenotype of compensat...

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Auteurs principaux: Lygate, Craig A., Medway, Debra J., Ostrowski, Philip J., Aksentijevic, Dunja, Sebag-Montefiore, Liam, Hunyor, Imre, Zervou, Sevasti, Schneider, Jurgen E., Neubauer, Stefan
Format: Artigo
Langue:Inglês
Publié: Springer-Verlag 2012
Sujets:
Original Contribution
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3442167/
https://ncbi.nlm.nih.gov/pubmed/22760499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-012-0276-2
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