Chronic creatine kinase deficiency eventually leads to congestive heart failure, but severity is dependent on genetic background, gender and age

The creatine kinase (CK) energy transport and buffering system supports cardiac function at times of high demand and is impaired in the failing heart. Mice deficient in muscle- and mitochondrial-CK (M/Mt-CK(−/−)) have previously been described, but exhibit an unexpectedly mild phenotype of compensat...

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Detalhes bibliográficos
Main Authors: Lygate, Craig A., Medway, Debra J., Ostrowski, Philip J., Aksentijevic, Dunja, Sebag-Montefiore, Liam, Hunyor, Imre, Zervou, Sevasti, Schneider, Jurgen E., Neubauer, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2012
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Original Contribution
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3442167/
https://ncbi.nlm.nih.gov/pubmed/22760499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-012-0276-2
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