A role for thioredoxin-interacting protein (Txnip) in cellular creatine homeostasis

Creatine is important for energy metabolism, yet excitable cells such as cardiomyocytes do not synthesize creatine and rely on uptake via a specific membrane creatine transporter (CrT; SLC6A8). This process is tightly controlled with downregulation of CrT upon continued exposure to high creatine via...

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Autori principali: Zervou, Sevasti, Ray, Tanmoy, Sahgal, Natasha, Sebag-Montefiore, Liam, Cross, Rebecca, Medway, Debra J., Ostrowski, Philip J., Neubauer, Stefan, Lygate, Craig A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725544/
https://ncbi.nlm.nih.gov/pubmed/23715727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00637.2012
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