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Nox4 reprograms cardiac substrate metabolism via protein O-GlcNAcylation to enhance stress adaptation

Cardiac hypertrophic remodeling during chronic hemodynamic stress is associated with a switch in preferred energy substrate from fatty acids to glucose, usually considered to be energetically favorable. The mechanistic interrelationship between altered energy metabolism, remodeling, and function rem...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Nabeebaccus, Adam A., Zoccarato, Anna, Hafstad, Anne D., Santos, Celio X.C., Aasum, Ellen, Brewer, Alison C., Zhang, Min, Beretta, Matteo, Yin, Xiaoke, West, James A., Schröder, Katrin, Griffin, Julian L., Eykyn, Thomas R., Abel, E. Dale, Mayr, Manuel, Shah, Ajay M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752273/
https://ncbi.nlm.nih.gov/pubmed/29263294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.96184
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