Nox4 reprograms cardiac substrate metabolism via protein O-GlcNAcylation to enhance stress adaptation

Cardiac hypertrophic remodeling during chronic hemodynamic stress is associated with a switch in preferred energy substrate from fatty acids to glucose, usually considered to be energetically favorable. The mechanistic interrelationship between altered energy metabolism, remodeling, and function rem...

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發表在:JCI Insight
Main Authors: Nabeebaccus, Adam A., Zoccarato, Anna, Hafstad, Anne D., Santos, Celio X.C., Aasum, Ellen, Brewer, Alison C., Zhang, Min, Beretta, Matteo, Yin, Xiaoke, West, James A., Schröder, Katrin, Griffin, Julian L., Eykyn, Thomas R., Abel, E. Dale, Mayr, Manuel, Shah, Ajay M.
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2017
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752273/
https://ncbi.nlm.nih.gov/pubmed/29263294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.96184
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