Lactate and Choline Metabolites Detected In Vitro by Nuclear Magnetic Resonance Spectroscopy Are Potential Metabolic Biomarkers for PI3K Inhibition in Pediatric Glioblastoma

The phosphoinositide 3-kinase (PI3K) pathway is believed to be of key importance in pediatric glioblastoma. Novel inhibitors of the PI3K pathway are being developed and are entering clinical trials. Our aim is to identify potential non-invasive biomarkers of PI3K signaling pathway inhibition in pedi...

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Detalhes bibliográficos
Main Authors: Al-Saffar, Nada M. S., Marshall, Lynley V., Jackson, L. Elizabeth, Balarajah, Geetha, Eykyn, Thomas R., Agliano, Alice, Clarke, Paul A., Jones, Chris, Workman, Paul, Pearson, Andrew D. J., Leach, Martin O.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4118961/
https://ncbi.nlm.nih.gov/pubmed/25084455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0103835
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