In vitro nuclear magnetic resonance spectroscopy metabolic biomarkers for the combination of temozolomide with PI3K inhibition in paediatric glioblastoma cells

Recent experimental data showed that the PI3K pathway contributes to resistance to temozolomide (TMZ) in paediatric glioblastoma and that this effect is reversed by combination treatment of TMZ with a PI3K inhibitor. Our aim is to assess whether this combination results in metabolic changes that are...

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Udgivet i:PLoS One
Main Authors: Al-Saffar, Nada M. S., Agliano, Alice, Marshall, Lynley V., Jackson, L. Elizabeth, Balarajah, Geetha, Sidhu, Jasmin, Clarke, Paul A., Jones, Chris, Workman, Paul, Pearson, Andrew D. J., Leach, Martin O.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5509135/
https://ncbi.nlm.nih.gov/pubmed/28704425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180263
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