Modification of intracellular glutathione status does not change the cardiac trapping of (64)Cu(ATSM)

BACKGROUND: The trapping mechanisms of the PET hypoxia imaging agent copper(II)-diacetyl-bis(N(4)-methylthiosemicarbazone) ((64)Cu(ATSM)) remain unresolved, although its reduction prior to dissociation may be mediated by intracellular thiols. Glutathione (GSH) is the most abundant intracellular thio...

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Publicat a:EJNMMI Res
Autors principals: Shaughnessy, Fiona, Mariotti, Erika, Shaw, Karen P, Eykyn, Thomas R, Blower, Philip J, Siow, Richard, Southworth, Richard
Format: Artigo
Idioma:Inglês
Publicat: Springer Berlin Heidelberg 2014
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4883992/
https://ncbi.nlm.nih.gov/pubmed/26055939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13550-014-0040-8
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