MCT1 inhibitor AZD3965 increases mitochondrial metabolism, facilitating combination therapy and non-invasive magnetic resonance spectroscopy

Monocarboxylate transporters (MCT) modulate tumor cell metabolism and offer promising therapeutic targets for cancer treatment. Understanding the impact of MCT blockade on tumor cell metabolism may help develop combination strategies or identify pharmacodynamic biomarkers to support the clinical dev...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Cancer Res
Huvudupphovsmän: Beloueche-Babari, Mounia, Wantuch, Slawomir, Casals Galobart, Teresa, Koniordou, Markella, Parkes, Harold G, Arunan, Vaitha, Chung, Yuen-Li, Eykyn, Thomas R, Smith, Paul D, Leach, Martin O
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669455/
https://ncbi.nlm.nih.gov/pubmed/28923861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-2686
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk