MCT1 inhibitor AZD3965 increases mitochondrial metabolism, facilitating combination therapy and non-invasive magnetic resonance spectroscopy

Monocarboxylate transporters (MCT) modulate tumor cell metabolism and offer promising therapeutic targets for cancer treatment. Understanding the impact of MCT blockade on tumor cell metabolism may help develop combination strategies or identify pharmacodynamic biomarkers to support the clinical dev...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Beloueche-Babari, Mounia, Wantuch, Slawomir, Casals Galobart, Teresa, Koniordou, Markella, Parkes, Harold G, Arunan, Vaitha, Chung, Yuen-Li, Eykyn, Thomas R, Smith, Paul D, Leach, Martin O
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669455/
https://ncbi.nlm.nih.gov/pubmed/28923861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-2686
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