Inhibition of Monocarboxylate transporter-1 (MCT1) by AZD3965 enhances radiosensitivity by reducing lactate transport

Inhibition of the monocarboxylate transporter MCT1 by AZD3965 results in an increase in glycolysis in human tumour cell lines and xenografts. This is indicated by changes in the levels of specific glycolytic metabolites and in changes in glycolytic enzyme kinetics. These drug-induced metabolic chang...

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Publicat a:Mol Cancer Ther
Autors principals: Bola, Becky M., Chadwick, Amy L., Michopoulos, Filippos, Blount, Kathryn G., Telfer, Brian A., Williams, Kaye J., Smith, Paul D, Critchlow, Susan E., Stratford, Ian J.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258406/
https://ncbi.nlm.nih.gov/pubmed/25281618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-1091
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