Activity of the Monocarboxylate Transporter 1 inhibitor AZD3965 in Small Cell Lung Cancer

PURPOSE: The monocarboxylate transporter 1 (MCT1) inhibitor AZD3965 is undergoing Phase I evaluation in the UK. AZD3965 is proposed, via lactate transport modulation, to kill tumor cells reliant on glycolysis. We investigated the therapeutic potential of AZD3965 in small cell lung cancer (SCLC) seek...

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Autori principali: Polański, Radosław, Hodgkinson, Cassandra L., Fusi, Alberto, Nonaka, Daisuke, Priest, Lynsey, Kelly, Paul, Trapani, Francesca, Bishop, Paul W., White, Anne, Critchlow, Susan E., Smith, Paul D., Blackhall, Fiona, Dive, Caroline, Morrow, Christopher J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929348/
https://ncbi.nlm.nih.gov/pubmed/24277449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-2270
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