PO27 IDH1 MUTATIONS COMPROMISE THE ADAPTIVE RESPONSE TO HYPOXIA

door Hollinshead, Kate E.R., Ludwig, Christian, Parker, Seth J., Metallo, Christian M., Critchlow, Susan E., Cruickshank, Garth S., Tennant, Daniel A.
Gepubliceerd in Neuro Oncol (2015)

CD147 subunit of lactate/H(+) symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors

door Le Floch, Renaud, Chiche, Johanna, Marchiq, Ibtissam, Naiken, Tanesha, Ilc, Karine, Murray, Clare M., Critchlow, Susan E., Roux, Danièle, Simon, Marie-Pierre, Pouysségur, Jacques
Gepubliceerd in 2011

Inhibition of Monocarboxylate transporter-1 (MCT1) by AZD3965 enhances radiosensitivity by reducing lactate transport

door Bola, Becky M., Chadwick, Amy L., Michopoulos, Filippos, Blount, Kathryn G., Telfer, Brian A., Williams, Kaye J., Smith, Paul D, Critchlow, Susan E., Stratford, Ian J.
Gepubliceerd in Mol Cancer Ther (2014)

Statin-induced metabolic reprogramming in head and neck cancer: a biomarker for targeting monocarboxylate transporters

door Mehibel, Manal, Ortiz-Martinez, Fernando, Voelxen, Nadine, Boyers, Amy, Chadwick, Amy, Telfer, Brian A., Mueller-Klieser, Wolfgang, West, Catharine M., Critchlow, Susan E., Williams, Kaye J., Stratford, Ian J.
Gepubliceerd in Sci Rep (2018)

3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers

door Jones, Dylan T., Valli, Alessandro, Haider, Syed, Zhang, Qifeng, Smethurst, Elizabeth A., Schug, Zachary T., Peck, Barrie, Aboagye, Eric O., Critchlow, Susan E., Schulze, Almut, Gottlieb, Eyal, Wakelam, Michael J.O., Harris, Adrian L.
Gepubliceerd in Mol Cancer Ther (2018)

Activity of the Monocarboxylate Transporter 1 inhibitor AZD3965 in Small Cell Lung Cancer

door Polański, Radosław, Hodgkinson, Cassandra L., Fusi, Alberto, Nonaka, Daisuke, Priest, Lynsey, Kelly, Paul, Trapani, Francesca, Bishop, Paul W., White, Anne, Critchlow, Susan E., Smith, Paul D., Blackhall, Fiona, Dive, Caroline, Morrow, Christopher J.
Gepubliceerd in 2013

Pre-clinical pharmacology of AZD3965, a selective inhibitor of MCT1: DLBCL, NHL and Burkitt’s lymphoma anti-tumor activity

door Curtis, Nicola J., Mooney, Lorraine, Hopcroft, Lorna, Michopoulos, Filippos, Whalley, Nichola, Zhong, Haihong, Murray, Clare, Logie, Armelle, Revill, Mitchell, Byth, Kate F., Benjamin, Amanda D., Firth, Mike A., Green, Stephen, Smith, Paul D., Critchlow, Susan E.
Gepubliceerd in Oncotarget (2017)

Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and Burkitt lymphoma

door Noble, Richard A., Bell, Natalie, Blair, Helen, Sikka, Arti, Thomas, Huw, Phillips, Nicole, Nakjang, Sirintra, Miwa, Satomi, Crossland, Rachel, Rand, Vikki, Televantou, Despina, Long, Anna, Keun, Hector C., Bacon, Chris M., Bomken, Simon, Critchlow, Susan E., Wedge, Stephen R.
Gepubliceerd in Haematologica (2017)

MCT1 modulates cancer cell pyruvate export and growth of tumors that co-express MCT1 and MCT4

door Hong, Candice Sun, Graham, Nicholas A., Gu, Wen, Camacho, Carolina Espindola, Mah, Vei, Maresh, Erin L., Alavi, Mohammed, Bagryanova, Lora, Krotee, Pascal A. L., Gardner, Brian K., Behbahan, Iman Saramipoor, Horvath, Steve, Chia, David, Mellinghoff, Ingo K., Hurvitz, Sara A., Dubinett, Steven M., Critchlow, Susan E., Kurdistani, Siavash K., Goodglick, Lee, Braas, Daniel, Graeber, Thomas G., Christofk, Heather R.
Gepubliceerd in Cell Rep (2016)

Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments

door Peck, Barrie, Schug, Zachary T., Zhang, Qifeng, Dankworth, Beatrice, Jones, Dylan T., Smethurst, Elizabeth, Patel, Rachana, Mason, Susan, Jiang, Ming, Saunders, Rebecca, Howell, Michael, Mitter, Richard, Spencer-Dene, Bradley, Stamp, Gordon, McGarry, Lynn, James, Daniel, Shanks, Emma, Aboagye, Eric O., Critchlow, Susan E., Leung, Hing Y., Harris, Adrian L., Wakelam, Michael J. O., Gottlieb, Eyal, Schulze, Almut
Gepubliceerd in Cancer Metab (2016)

AZD3514: a small molecule that modulates androgen receptor signaling and function in vitro and in vivo

door Loddick, Sarah A, Ross, Sarah J, Thomason, Andrew G, Robinson, David M, Walker, Graeme E, Dunkley, Tom PJ, Brave, Sandra R, Broadbent, Nicola, Stratton, Natalie C, Trueman, Dawn, Mouchet, Elizabeth, Shaheen, Fadhel S, Jacobs, Vivien N, Cumberbatch, Marie, Wilson, Joanne, Jones, Rhys D O, Bradbury, Robert H, Rabow, Alfred, Gaughan, Luke, Womack, Chris, Barry, Simon T, Robson, Craig N, Critchlow, Susan E, Wedge, Stephen R, Brooks, Nigel A
Gepubliceerd in 2013

Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress

door Schug, Zachary T., Peck, Barrie, Jones, Dylan T., Zhang, Qifeng, Grosskurth, Shaun, Alam, Israt S., Goodwin, Louise M., Smethurst, Elizabeth, Mason, Susan, Blyth, Karen, McGarry, Lynn, James, Daniel, Shanks, Emma, Kalna, Gabriela, Saunders, Rebecca E., Jiang, Ming, Howell, Michael, Lassailly, Francois, Thin, May Zaw, Spencer-Dene, Bradley, Stamp, Gordon, van den Broek, Niels J.F., Mackay, Gillian, Bulusu, Vinay, Kamphorst, Jurre J., Tardito, Saverio, Strachan, David, Harris, Adrian L., Aboagye, Eric O., Critchlow, Susan E., Wakelam, Michael J.O., Schulze, Almut, Gottlieb, Eyal
Gepubliceerd in Cancer Cell (2015)