Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress

A functional genomics study revealed that the activity of acetyl-CoA synthetase 2 (ACSS2) contributes to cancer cell growth under low-oxygen and lipid-depleted conditions. Comparative metabolomics and lipidomics demonstrated that acetate is used as a nutritional source by cancer cells in an ACSS2-de...

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Veröffentlicht in:Cancer Cell
Hauptverfasser: Schug, Zachary T., Peck, Barrie, Jones, Dylan T., Zhang, Qifeng, Grosskurth, Shaun, Alam, Israt S., Goodwin, Louise M., Smethurst, Elizabeth, Mason, Susan, Blyth, Karen, McGarry, Lynn, James, Daniel, Shanks, Emma, Kalna, Gabriela, Saunders, Rebecca E., Jiang, Ming, Howell, Michael, Lassailly, Francois, Thin, May Zaw, Spencer-Dene, Bradley, Stamp, Gordon, van den Broek, Niels J.F., Mackay, Gillian, Bulusu, Vinay, Kamphorst, Jurre J., Tardito, Saverio, Strachan, David, Harris, Adrian L., Aboagye, Eric O., Critchlow, Susan E., Wakelam, Michael J.O., Schulze, Almut, Gottlieb, Eyal
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297291/
https://ncbi.nlm.nih.gov/pubmed/25584894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2014.12.002
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