Hypoxia and oxidative stress in breast cancer: Tumour hypoxia – therapeutic considerations

Por Williams, Kaye J, Cowen, Rachel L, Stratford, Ian J
Publicado em 2001

Comparison of Doxycycline Delivery Methods for Tet-Inducible Gene Expression in a Subcutaneous Xenograft Model

Por Cawthorne, Christopher, Swindell, Ric, Stratford, Ian J., Dive, Caroline, Welman, Arkadiusz
Publicado em 2007

Dissecting the role of multiple reductases in bioactivation and cytotoxicity of the antitumor agent RH1

Por Yan, Chao, Kepa, Jadwiga K., Siegel, David, Stratford, Ian J., Ross, David
Publicado em 2008

Radiation enhances the therapeutic effect of Banoxantrone in hypoxic tumour cells with elevated levels of nitric oxide synthase

Por MEHIBEL, MANAL, SINGH, SIMENDRA, COWEN, RACHEL L., WILLIAMS, KAYE J., STRATFORD, IAN J.
Publicado no Oncol Rep (2016)

PCAF is a HIF-1α cofactor that regulates p53 transcriptional activity in hypoxia

Por Xenaki, Georgia, Ontikatze, Teona, Rajendran, Ramkumar, Stratford, Ian J., Dive, Caroline, Krstic-Demonacos, Marija, Demonacos, Constantinos
Publicado em 2008

In silico screening reveals structurally diverse, nanomolar inhibitors of NQO2 that are functionally active in cells and can modulate NFκB signalling

Por Nolan, Karen A., Dunstan, Mark S., Caraher, Mary C., Scott, Katherine A., Leys, David, Stratford, Ian J.
Publicado em 2011

Site and Strain-Specific Variation in Gut Microbiota Profiles and Metabolism in Experimental Mice

Por Friswell, Melissa K., Gika, Helen, Stratford, Ian J., Theodoridis, Georgios, Telfer, Brian, Wilson, Ian D., McBain, Andrew J.
Publicado em 2010

The two common polymorphic forms of human NRH-quinone oxidoreductase 2 (NQO2) have different biochemical properties

Por Megarity, Clare F., Gill, James R.E., Clare Caraher, M., Stratford, Ian J., Nolan, Karen A., Timson, David J.
Publicado em 2014

Akt inhibition improves long‐term tumour control following radiotherapy by altering the microenvironment

Por Searle, Emma J, Telfer, Brian A, Mukherjee, Debayan, Forster, Duncan M, Davies, Barry R, Williams, Kaye J, Stratford, Ian J, Illidge, Tim M
Publicado no EMBO Mol Med (2017)

Hypoxia-Mediated Down-Regulation of Bid and Bax in Tumors Occurs via Hypoxia-Inducible Factor 1-Dependent and -Independent Mechanisms and Contributes to Drug Resistance

Por Erler, Janine T., Cawthorne, Christopher J., Williams, Kaye J., Koritzinsky, Marianne, Wouters, Bradley G., Wilson, Clare, Miller, Crispin, Demonacos, Costas, Stratford, Ian J., Dive, Caroline
Publicado em 2004

Glucocorticoid receptor over-expression promotes human small cell lung cancer apoptosis in vivo and thereby slows tumor growth

Por Sommer, Paula, Cowen, Rachel L, Berry, Andrew, Cookson, Ann, Telfer, Brian A, Williams, Kaye J, Stratford, Ian J, Kay, Paul, White, Anne, Ray, David W
Publicado em 2010

Inhibition of poly(ADP-ribose) polymerase-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft

Por Senra, Joana M., Telfer, Brian A., Cherry, Kim E., McCrudden, Cian M., Hirst, David G., O’Connor, Mark J., Wedge, Stephen R., Stratford, Ian J.
Publicado em 2011

Inhibition of Monocarboxylate transporter-1 (MCT1) by AZD3965 enhances radiosensitivity by reducing lactate transport

Por Bola, Becky M., Chadwick, Amy L., Michopoulos, Filippos, Blount, Kathryn G., Telfer, Brian A., Williams, Kaye J., Smith, Paul D, Critchlow, Susan E., Stratford, Ian J.
Publicado no Mol Cancer Ther (2014)

Hypoxia and hyperglycaemia determine why some endometrial tumours fail to respond to metformin

Por Sivalingam, Vanitha N., Latif, Ayşe, Kitson, Sarah, McVey, Rhona, Finegan, Katherine G., Marshall, Kay, Lisanti, Michael P., Sotgia, Federica, Stratford, Ian J., Crosbie, Emma J.
Publicado no Br J Cancer (2019)

Statin-induced metabolic reprogramming in head and neck cancer: a biomarker for targeting monocarboxylate transporters

Por Mehibel, Manal, Ortiz-Martinez, Fernando, Voelxen, Nadine, Boyers, Amy, Chadwick, Amy, Telfer, Brian A., Mueller-Klieser, Wolfgang, West, Catharine M., Critchlow, Susan E., Williams, Kaye J., Stratford, Ian J.
Publicado no Sci Rep (2018)

A novel systemically administered toll-like receptor 7 agonist potentiates the effect of ionizing radiation in murine solid tumor models

Por Adlard, Amy L, Dovedi, Simon J, Telfer, Brian A, Koga-Yamakawa, Erina, Pollard, Charlotte, Honeychurch, Jamie, Illidge, Timothy M, Murata, Masashi, Robinson, David T, Jewsbury, Philip J, Wilkinson, Robert W, Stratford, Ian J
Publicado no Int J Cancer (2014)

Utilizing the adjuvant properties of CD1d-dependent NK T cells in T cell–mediated immunotherapy

Por Silk, Jonathan D., Hermans, Ian F., Gileadi, Uzi, Chong, Tsung Wen, Shepherd, Dawn, Salio, Mariolina, Mathew, Bini, Schmidt, Richard R., Lunt, Sarah Jane, Williams, Kaye J., Stratford, Ian J., Harris, Adrian L., Cerundolo, Vincenzo
Publicado em 2004

Monocarboxylate Transporter 1 (MCT1) is an independent prognostic biomarker in endometrial cancer

Por Latif, Ayşe, Chadwick, Amy L., Kitson, Sarah J., Gregson, Hannah J., Sivalingam, Vanitha N., Bolton, James, McVey, Rhona J., Roberts, Stephen A., Marshall, Kay M., Williams, Kaye J., Stratford, Ian J., Crosbie, Emma J.
Publicado no BMC Clin Pathol (2017)

Intravenous administration of the selective toll-like receptor 7 agonist DSR-29133 leads to anti-tumor efficacy in murine solid tumor models which can be potentiated by combination...

Por Dovedi, Simon J., Adlard, Amy L., Ota, Yosuke, Murata, Masashi, Sugaru, Eiji, Koga-Yamakawa, Erina, Eguchi, Ken, Hirose, Yuko, Yamamoto, Setsuko, Umehara, Hiroki, Honeychurch, Jamie, Cheadle, Eleanor J., Hughes, Gareth, Jewsbury, Philip J., Wilkinson, Robert W., Stratford, Ian J., Illidge, Timothy M.
Publicado no Oncotarget (2016)

Expression of NAD(P)H quinone dehydrogenase 1 (NQO1) is increased in the endometrium of women with endometrial cancer and women with polycystic ovary syndrome

Por Atiomo, William, Shafiee, Mohamad Nasir, Chapman, Caroline, Metzler, Veronika M., Abouzeid, Jad, Latif, Ayşe, Chadwick, Amy, Kitson, Sarah, Sivalingam, Vanitha N., Stratford, Ian J., Rutland, Catrin S., Persson, Jenny L., Ødum, Niels, Fuentes‐Utrilla, Pablo, Jeyapalan, Jennie N., Heery, David M., Crosbie, Emma J., Mongan, Nigel P.
Publicado no Clin Endocrinol (Oxf) (2017)