Inhibition of poly(ADP-ribose) polymerase-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft

Poly(ADP-ribose) polymerase-1 is a critical enzyme in the repair of DNA strand breaks. Inhibition of PARP-1 increases the effectiveness of radiation in killing tumor cells. However, while the mechanism(s) are well understood for these radiosensitizing effects in vitro, the underlying mechanism(s) in...

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Detaylı Bibliyografya
Asıl Yazarlar: Senra, Joana M., Telfer, Brian A., Cherry, Kim E., McCrudden, Cian M., Hirst, David G., O’Connor, Mark J., Wedge, Stephen R., Stratford, Ian J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2011
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3192032/
https://ncbi.nlm.nih.gov/pubmed/21825006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-11-0278
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