Vasoactivity of AG014699, a clinically active small molecule inhibitor of poly(ADP-ribose) polymerase: a contributory factor to chemopotentiation in vivo?

PURPOSE: Poly(ADP-ribose) polymerase plays an important role in DNA repair and PARP inhibitors can enhance the activity of DNA damaging agents in vitro and in vivo. AG014699 is a potent PARP inhibitor in Phase II clinical development. However the range of therapeutics with which AG014699 could inter...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Ali, Majid, Telfer, Brian A, McCrudden, Cian, O’Rourke, Martin, Thomas, Huw D, Kamjoo, Marzieh, Kyle, Suzanne, Robson, Tracy, Shaw, Chris, Hirst, David G., Curtin, Nicola J, Williams, Kaye J
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2009
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2756456/
https://ncbi.nlm.nih.gov/pubmed/19789326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-0398
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