Hypoxia and hyperglycaemia determine why some endometrial tumours fail to respond to metformin

BACKGROUND: High expression of Ki67, a proliferation marker, is associated with reduced endometrial cancer-specific survival. Pre-surgical metformin reduces tumour Ki-67 expression in some women with endometrial cancer. Metformin’s anti-cancer activity may relate to effects on cellular energy metabo...

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Vydáno v:Br J Cancer
Hlavní autoři: Sivalingam, Vanitha N., Latif, Ayşe, Kitson, Sarah, McVey, Rhona, Finegan, Katherine G., Marshall, Kay, Lisanti, Michael P., Sotgia, Federica, Stratford, Ian J., Crosbie, Emma J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6964676/
https://ncbi.nlm.nih.gov/pubmed/31819173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-019-0627-y
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