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Hypoxia and hyperglycaemia determine why some endometrial tumours fail to respond to metformin
BACKGROUND: High expression of Ki67, a proliferation marker, is associated with reduced endometrial cancer-specific survival. Pre-surgical metformin reduces tumour Ki-67 expression in some women with endometrial cancer. Metformin’s anti-cancer activity may relate to effects on cellular energy metabo...
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| 出版年: | Br J Cancer |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6964676/ https://ncbi.nlm.nih.gov/pubmed/31819173 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-019-0627-y |
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