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PCAF is a HIF-1α cofactor that regulates p53 transcriptional activity in hypoxia
The p53 tumour suppressor is involved in several crucial cellular functions including cell cycle arrest and apoptosis. p53 stabilisation occurs under hypoxic and DNA damage conditions. However, only in the latter scenario is stabilised p53 capable of inducing the expression of its pro-apoptotic targ...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2664615/ https://ncbi.nlm.nih.gov/pubmed/18574470 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2008.192 |
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