Ex vivo treatment of patient biopsies as a novel method to assess colorectal tumour response to the MEK1/2 inhibitor, Selumetinib

Por Novo, Sonia M., Wedge, Stephen R., Stark, Lesley A.
Publicado no Sci Rep (2017)

Tumor cells with KRAS or BRAF mutations or ERK5/MAPK7 amplification are not addicted to ERK5 activity for cell proliferation

Por Lochhead, Pamela A., Clark, Jonathan, Wang, Lan-Zhen, Gilmour, Lesley, Squires, Matthew, Gilley, Rebecca, Foxton, Caroline, Newell, David R., Wedge, Stephen R., Cook, Simon J.
Publicado no Cell Cycle (2016)

Inhibition of poly(ADP-ribose) polymerase-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft

Por Senra, Joana M., Telfer, Brian A., Cherry, Kim E., McCrudden, Cian M., Hirst, David G., O’Connor, Mark J., Wedge, Stephen R., Stratford, Ian J.
Publicado em 2011

Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System

Por Hallett, Stephen T., Pastok, Martyna W., Morgan, R. Marc L., Wittner, Anita, Blundell, Katie L.I.M., Felletar, Ildiko, Wedge, Stephen R., Prodromou, Chrisostomos, Noble, Martin E.M., Pearl, Laurence H., Endicott, Jane A.
Publicado no Cell Rep (2017)

Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and Burkitt lymphoma

Por Noble, Richard A., Bell, Natalie, Blair, Helen, Sikka, Arti, Thomas, Huw, Phillips, Nicole, Nakjang, Sirintra, Miwa, Satomi, Crossland, Rachel, Rand, Vikki, Televantou, Despina, Long, Anna, Keun, Hector C., Bacon, Chris M., Bomken, Simon, Critchlow, Susan E., Wedge, Stephen R.
Publicado no Haematologica (2017)

Identification and Characterization of an Irreversible Inhibitor of CDK2

Por Anscombe, Elizabeth, Meschini, Elisa, Mora-Vidal, Regina, Martin, Mathew P., Staunton, David, Geitmann, Matthis, Danielson, U. Helena, Stanley, Will A., Wang, Lan Z., Reuillon, Tristan, Golding, Bernard T., Cano, Celine, Newell, David R., Noble, Martin E.M., Wedge, Stephen R., Endicott, Jane A., Griffin, Roger J.
Publicado no Chem Biol (2015)

Capturing complex tumour biology in vitro: histological and molecular characterisation of precision cut slices

Por Davies, Emma J., Dong, Meng, Gutekunst, Matthias, Närhi, Katja, van Zoggel, Hanneke J. A. A., Blom, Sami, Nagaraj, Ashwini, Metsalu, Tauno, Oswald, Eva, Erkens-Schulze, Sigrun, Delgado San Martin, Juan A., Turkki, Riku, Wedge, Stephen R., af Hällström, Taija M., Schueler, Julia, van Weerden, Wytske M., Verschuren, Emmy W., Barry, Simon T., van der Kuip, Heiko, Hickman, John A.
Publicado no Sci Rep (2015)

AZD3514: a small molecule that modulates androgen receptor signaling and function in vitro and in vivo

Por Loddick, Sarah A, Ross, Sarah J, Thomason, Andrew G, Robinson, David M, Walker, Graeme E, Dunkley, Tom PJ, Brave, Sandra R, Broadbent, Nicola, Stratton, Natalie C, Trueman, Dawn, Mouchet, Elizabeth, Shaheen, Fadhel S, Jacobs, Vivien N, Cumberbatch, Marie, Wilson, Joanne, Jones, Rhys D O, Bradbury, Robert H, Rabow, Alfred, Gaughan, Luke, Womack, Chris, Barry, Simon T, Robson, Craig N, Critchlow, Susan E, Wedge, Stephen R, Brooks, Nigel A
Publicado em 2013