Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System

Selective recruitment of protein kinases to the Hsp90 system is mediated by the adaptor co-chaperone Cdc37. We show that assembly of CDK4 and CDK6 into protein complexes is differentially regulated by the Cdc37-Hsp90 system. Like other Hsp90 kinase clients, binding of CDK4/6 to Cdc37 is blocked by A...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Hallett, Stephen T., Pastok, Martyna W., Morgan, R. Marc L., Wittner, Anita, Blundell, Katie L.I.M., Felletar, Ildiko, Wedge, Stephen R., Prodromou, Chrisostomos, Noble, Martin E.M., Pearl, Laurence H., Endicott, Jane A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5681435/
https://ncbi.nlm.nih.gov/pubmed/29091774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.10.042
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