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ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system
Protein kinase clients are recruited to the Hsp90 molecular chaperone system via Cdc37, which simultaneously binds Hsp90 and kinases and regulates the Hsp90 chaperone cycle. Pharmacological inhibition of Hsp90 in vivo results in degradation of kinase clients, with a therapeutic effect in dependent t...
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| Wydane w: | Nat Chem Biol |
|---|---|
| Główni autorzy: | , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2013
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5695660/ https://ncbi.nlm.nih.gov/pubmed/23502424 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1212 |
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