Restricting direct interaction of CDC37 with HSP90 does not compromise chaperoning of client proteins

The HSP90 molecular chaperone plays a key role in the maturation, stability and activation of its clients, including many oncogenic proteins. Kinases are a substantial and important subset of clients requiring the key cochaperone CDC37. We sought an improved understanding of protein kinase chaperoni...

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Main Authors: Smith, Jennifer R., de Billy, Emmanuel, Hobbs, Stephen, Powers, Marissa, Prodromou, Chrisostomos, Pearl, Laurence, Clarke, Paul A., Workman, Paul
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3984902/
https://ncbi.nlm.nih.gov/pubmed/24292678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.519
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