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Restricting direct interaction of CDC37 with HSP90 does not compromise chaperoning of client proteins
The HSP90 molecular chaperone plays a key role in the maturation, stability and activation of its clients, including many oncogenic proteins. Kinases are a substantial and important subset of clients requiring the key cochaperone CDC37. We sought an improved understanding of protein kinase chaperoni...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3984902/ https://ncbi.nlm.nih.gov/pubmed/24292678 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.519 |
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