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Targeting the Hsp90-Cdc37-client protein interaction to disrupt Hsp90 chaperone machinery

Heat shock protein 90 (Hsp90) is a critical molecular chaperone protein that regulates the folding, maturation, and stability of a wide variety of proteins. In recent years, the development of Hsp90-directed inhibitors has grown rapidly, and many of these inhibitors have entered clinical trials. In...

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Bibliografski detalji
Izdano u:J Hematol Oncol
Glavni autori: Li, Ting, Jiang, Hu-Lin, Tong, Yun-Guang, Lu, Jin-Jian
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5921262/
https://ncbi.nlm.nih.gov/pubmed/29699578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-018-0602-8
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