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Characterization of Celastrol to Inhibit Hsp90 and Cdc37 Interaction

The molecular chaperone heat shock protein 90 (Hsp90) is required for the stabilization and conformational maturation of various oncogenic proteins in cancer. The loading of protein kinases to Hsp90 is actively mediated by the cochaperone Cdc37. The crucial role of the Hsp90-Cdc37 complex has made i...

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Autori principali: Zhang, Tao, Li, Yanyan, Yu, Yanke, Zou, Peng, Jiang, Yiqun, Sun, Duxin
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790967/
https://ncbi.nlm.nih.gov/pubmed/19858214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.051532
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