Mutations Y493G and K546D in human HSP90 disrupt binding of celastrol and reduce interaction with Cdc37

Celastrol, a natural compound derived from the Chinese herb Tripterygium wilfordii Hook F, has been proven to inhibit heat shock protein 90 (HSP90) activity and has attracted much attention because of its promising effects in cancer treatment and in ameliorating degenerative neuron diseases. However...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:FEBS Open Bio
Egile Nagusiak: Peng, Bin, Gu, Yi‐Jun, Wang, Ying, Cao, Fan‐Fan, Zhang, Xue, Zhang, Deng‐Hai, Hou, Jian
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2016
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4932452/
https://ncbi.nlm.nih.gov/pubmed/27398312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12081
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